Clinical significance of right atrial volume in patients with repaired tetralogy of Fallot

Interact Cardiovasc Thorac Surg. 2020 Feb 1;30(2):296-302. doi: 10.1093/icvts/ivz254.

Abstract

Objectives: Atrial arrhythmia and right ventricular (RV) diastolic dysfunction are associated with increased morbidity and mortality in patients with repaired tetralogy of Fallot (TOF). This study was performed to determine whether the preoperative right atrial (RA) volume can predict the development of atrial arrhythmia after pulmonary valve replacement (PVR) in patients with TOF.

Methods: Forty-seven consecutive adult patients with repaired TOF underwent PVR from 2003 to 2018. Seventeen patients showed preoperative atrial arrhythmia and underwent the Maze procedure concomitantly. The preoperative RA volume was evaluated with computed tomography and image analysis software.

Results: The median follow-up period after PVR was 6.8 years. Among 17 patients who underwent the Maze procedure, recurrent atrial arrhythmia developed in 8 patients. Among 30 patients without preoperative atrial arrhythmia, novel atrial arrhythmia developed in 2 patients. The RA volume index was a significant predictor according to the multivariate analysis (P = 0.003). The RA volume index showed a significant positive correlation with the RV end-diastolic pressure (P < 0.001).

Conclusions: The RA volume predicts the development of atrial arrhythmia after PVR in patients with repaired TOF. RA volume measurement is strongly recommended in the management of this patient population.

Keywords: Atrial arrhythmia; Pulmonary valve replacement; Repaired tetralogy of Fallot; Right atrial volume.

MeSH terms

  • Adolescent
  • Adult
  • Cardiac Surgical Procedures / methods*
  • Cardiac Volume*
  • Female
  • Heart Atria / diagnostic imaging
  • Heart Atria / physiopathology*
  • Humans
  • Male
  • Middle Aged
  • Tetralogy of Fallot / surgery*
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Young Adult