Does Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea Improves Uric Acid? A Meta-Analysis

Qingshi Chen; Guofu Lin; Lida Chen; Jiefeng Huang; Yaping Huang; Ping Li; Mengxue Chen; Qichang Lin

doi:10.1155/2019/4584936

Does Continuous Positive Airway Pressure Therapy in Patients with Obstructive Sleep Apnea Improves Uric Acid? A Meta-Analysis

Oxid Med Cell Longev. 2019 Sep 15:2019:4584936. doi: 10.1155/2019/4584936. eCollection 2019.

Authors

Qingshi Chen^{1

2}, Guofu Lin¹, Lida Chen^{1

3}, Jiefeng Huang¹, Yaping Huang³, Ping Li², Mengxue Chen¹, Qichang Lin¹

Affiliations

¹ Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Taijiang District, Fuzhou 350005, China.
² The Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Licheng District, Quanzhou 362000, China.
³ Department of Respiratory and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, No. 59, Shenglixi Road, Xiangcheng District, Zhangzhou 363000, China.

Abstract

Purpose: The efficacy of obstructive sleep apnea (OSA) therapy with continuous positive airway pressure (CPAP) on uric acid (UA) yielded conflicting results. This meta-analysis was performed to assess whether OSA treatment with CPAP could reduce UA levels.

Methods: The Web of Science, Cochrane Library, Embase, and PubMed were searched before March 2019. Information of patients, study design, and pre- and post-CPAP treatment of UA was utilized for analysis. The overall effects were analyzed via the standardized mean difference (SMD) with a 95% confidence interval (CI). Five studies were obtained and the meta-analysis was performed using Stata 12.0 and Review Manager 5.2.

Results: A total of 5 studies with 6 cohorts (2 RCT and 3 observational studies) involving 270 patients were pooled into meta-analysis. There was no change of UA levels before and after CPAP treatment in OSA patients (SMD = -0.20, 95% CI: -0.78 to 0.37, Z = 0.69, p = 0.49). Subgroup analysis showed that the outcomes were not affected by age of patients, gender distribution, baseline body mass index, daily duration, duration of CPAP treatment, sample size, and study design.

Conclusions: This meta-analysis revealed that CPAP treatment has no effect on UA in OSA patients. Further well-designed, large-scale randomized controlled trials are required to address this issue.

Publication types

Meta-Analysis
Review

MeSH terms

Continuous Positive Airway Pressure / methods*
Female
Humans
Male
Sleep Apnea, Obstructive / therapy*
Uric Acid / metabolism*

Substances

Uric Acid