A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy

Chem Commun (Camb). 2019 Nov 18;55(89):13374-13377. doi: 10.1039/c9cc06043j. Epub 2019 Oct 21.

Abstract

Cancer cells adapt to cellular oxidative stress by increasing glutathione (GSH). An organically modified silica nanosystem (ORMOSIL@GOx) was fabricated to achieve a lethal level of oxidative stress in cancer cells by depleting intracellular GSH while increasing reactive oxygen species.

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Drug Screening Assays, Antitumor
  • Glucose / deficiency*
  • Glucose / metabolism
  • Glutathione / metabolism*
  • Humans
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Neoplasms / diet therapy*
  • Neoplasms / metabolism*
  • Organosilicon Compounds / chemical synthesis
  • Organosilicon Compounds / chemistry
  • Organosilicon Compounds / pharmacology*
  • Oxidative Stress / drug effects
  • Particle Size
  • Reactive Oxygen Species / metabolism*
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Organosilicon Compounds
  • Reactive Oxygen Species
  • Glutathione
  • Glucose