Abstract
Cancer cells adapt to cellular oxidative stress by increasing glutathione (GSH). An organically modified silica nanosystem (ORMOSIL@GOx) was fabricated to achieve a lethal level of oxidative stress in cancer cells by depleting intracellular GSH while increasing reactive oxygen species.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Drug Screening Assays, Antitumor
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Glucose / deficiency*
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Glucose / metabolism
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Glutathione / metabolism*
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Humans
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Molecular Structure
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Nanoparticles / chemistry*
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Neoplasms / diet therapy*
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Neoplasms / metabolism*
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Organosilicon Compounds / chemical synthesis
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Organosilicon Compounds / chemistry
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Organosilicon Compounds / pharmacology*
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Oxidative Stress / drug effects
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Particle Size
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Reactive Oxygen Species / metabolism*
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Surface Properties
Substances
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Antineoplastic Agents
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Organosilicon Compounds
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Reactive Oxygen Species
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Glutathione
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Glucose