The identification of gene-environment interactions related to breast cancer reveals the biological and molecular mechanisms underlying the disease and allows distinction of women at high risk from women at lower risk, which could decrease the morbi-mortality of this neoplasm. The current study evaluated the association between polymorphisms rs1820453 and rs11225161 of the YAP gene in women with breast cancer exposed to arsenic (As) through drinking water. The frequency of YAP rs1820453 and rs11225161 polymorphisms and As urinary levels were assessed in a total of 182 women. The results demonstrated a positive and significant association between breast cancer and smoking, type of drinking water, and levels of AsIII, AsV and inorganic arsenic (iAs) but not the YAP gene polymorphisms evaluated. In conclusion, our data showed that the source of drinking water and AsV and iAs urinary levels increase the risk for breast cancer, but no interactions between YAP gene polymorphisms and arsenic urinary levels were found.
The identification of gene-environment interactions related to breast cancer reveals the biological and molecular mechanisms underlying the disease and allows the distinction of women at high risk from women at lower risk, which could decrease the morbimortality of this neoplasm. The current study evaluated the association between polymorphisms rs1820453 and rs11225161 of the Yes-associated protein (YAP) gene in women with breast cancer exposed to arsenic (As) through drinking water. In total, 182 women were assessed for the frequency of YAP rs1820453 and rs11225161 polymorphisms and As urinary levels. The results demonstrated a positive and significant association between breast cancer and smoking, type of drinking water, and levels of AsIII , AsV and inorganic As (iAs) but not the YAP gene polymorphisms evaluated. In conclusion, our data showed that the source of drinking water and AsV and iAs urinary levels increased the risk for breast cancer, but no interactions between YAP gene polymorphisms and As urinary levels were found.
Keywords: YAP; YAP rs11225161 polymorphism; YAP rs1820453 polymorphism; Yes-associated protein; arsenic; breast cancer.