Joint utilization of genetic analysis and semi-cloning technology reveals a digenic etiology of Müllerian anomalies

Lingbo Wang; Ying Zhang; Xiaoyi Fu; Shuangshuang Dong; Shuyan Tang; Ning Zhang; Chengcheng Song; Nan Yang; Lin Zhang; Hongyan Wang; Huijuan Shi; Li Jin; Feng Zhang; Jinsong Li; Keqin Hua

doi:10.1038/s41422-019-0243-7

Joint utilization of genetic analysis and semi-cloning technology reveals a digenic etiology of Müllerian anomalies

Cell Res. 2020 Jan;30(1):91-94. doi: 10.1038/s41422-019-0243-7. Epub 2019 Oct 18.

Authors

Lingbo Wang^#^{1

2

3

4}, Ying Zhang^#^{1

3}, Xiaoyi Fu^#¹, Shuangshuang Dong^#^{1

3}, Shuyan Tang^{1

3

4}, Ning Zhang^{1

3}, Chengcheng Song^{1

3}, Nan Yang^{1

3}, Lin Zhang², Hongyan Wang^{1

3

4}, Huijuan Shi¹, Li Jin¹, Feng Zhang^{5

6

7}, Jinsong Li⁸, Keqin Hua^{9

10}

Affiliations

¹ Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, 200011, Shanghai, China.
² State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China.
³ Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, 200011, China.
⁴ Institute of Metabolism and Integrative Biology, Fudan University, 200438, Shanghai, China.
⁵ Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, 200011, Shanghai, China. zhangfeng@fudan.edu.cn.
⁶ Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, 200011, China. zhangfeng@fudan.edu.cn.
⁷ Institute of Metabolism and Integrative Biology, Fudan University, 200438, Shanghai, China. zhangfeng@fudan.edu.cn.
⁸ State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 200031, Shanghai, China. jsli@sibcb.ac.cn.
⁹ Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, 200011, Shanghai, China. huakeqin@fudan.edu.cn.
¹⁰ Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, 200011, China. huakeqin@fudan.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cloning, Molecular
DNA Copy Number Variations
Female
GATA3 Transcription Factor / genetics
Holliday Junction Resolvases / genetics
Humans
LIM-Homeodomain Proteins / genetics
Mice
Mullerian Ducts / abnormalities*
Mutation
T-Box Domain Proteins / genetics
Transcription Factors / genetics
Wnt Proteins / genetics

Substances

GATA3 Transcription Factor
GEN1 protein, mouse
Gata3 protein, mouse
LHX1 protein, human
LIM-Homeodomain Proteins
T-Box Domain Proteins
TBX6 protein, human
Transcription Factors
WNT9B protein, human
Wnt Proteins
Wnt9b protein, mouse
GEN1 protein, human
Holliday Junction Resolvases