Abstract
Von Hippel-Lindau protein (VHL) is associated with the development and progression of kidney cancer. An increase in VHL expression was found in patients with the disseminated form of the disease compared to the localized cancer, which was combined with a uniform distribution of decreased (<1.0) and increased (>1.0) VHL mRNA levels in renal cancer patients depending on the dissemination of the process. The increase in VHL expression was accompanied an increase in the level of mRNA for NF-κB p65 and kinases PDK1 and Akt. The revealed data indicate the importance of molecular biological parameters in oncogenesis.
Keywords:
VHL; components of Akt/m-TOR signaling pathway; growth factors; kidney cancer; nuclear factors.
MeSH terms
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Basic Helix-Loop-Helix Transcription Factors / genetics
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Basic Helix-Loop-Helix Transcription Factors / metabolism
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Carbonic Anhydrase IX / genetics*
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Carbonic Anhydrase IX / metabolism
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Carcinoma, Renal Cell / genetics*
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Carcinoma, Renal Cell / metabolism
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Carcinoma, Renal Cell / pathology
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Carcinoma, Renal Cell / surgery
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Gene Expression Profiling
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Gene Expression Regulation, Neoplastic*
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
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Kidney Neoplasms / genetics*
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Kidney Neoplasms / metabolism
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Kidney Neoplasms / pathology
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Kidney Neoplasms / surgery
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Lymphatic Metastasis
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Neoplasm Staging
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Proto-Oncogene Proteins c-akt / genetics
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Proto-Oncogene Proteins c-akt / metabolism
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Signal Transduction
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TOR Serine-Threonine Kinases / genetics
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TOR Serine-Threonine Kinases / metabolism
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Transcription Factor RelA / genetics
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Transcription Factor RelA / metabolism
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Vascular Endothelial Growth Factor A / genetics
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Vascular Endothelial Growth Factor A / metabolism
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Vascular Endothelial Growth Factor Receptor-2 / genetics*
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Vascular Endothelial Growth Factor Receptor-2 / metabolism
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Von Hippel-Lindau Tumor Suppressor Protein / genetics*
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Von Hippel-Lindau Tumor Suppressor Protein / metabolism
Substances
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Basic Helix-Loop-Helix Transcription Factors
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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Transcription Factor RelA
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VEGFA protein, human
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Vascular Endothelial Growth Factor A
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endothelial PAS domain-containing protein 1
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Von Hippel-Lindau Tumor Suppressor Protein
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MTOR protein, human
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KDR protein, human
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Vascular Endothelial Growth Factor Receptor-2
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Proto-Oncogene Proteins c-akt
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TOR Serine-Threonine Kinases
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Carbonic Anhydrase IX
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VHL protein, human