Primary Chest Wall Sarcoma: Surgical Outcomes and Prognostic Factors

Ilkun Park; Sumin Shin; Hong Kwan Kim; Yong Soo Choi; Jhingook Kim; Jae Ill Zo; Young Mog Shim; Jong Ho Cho

doi:10.5090/kjtcs.2019.52.5.360

Primary Chest Wall Sarcoma: Surgical Outcomes and Prognostic Factors

Korean J Thorac Cardiovasc Surg. 2019 Oct;52(5):360-367. doi: 10.5090/kjtcs.2019.52.5.360. Epub 2019 Oct 5.

Authors

Ilkun Park¹, Sumin Shin¹, Hong Kwan Kim¹, Yong Soo Choi¹, Jhingook Kim¹, Jae Ill Zo¹, Young Mog Shim¹, Jong Ho Cho¹

Affiliation

¹ Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Abstract

Background: Primary chest wall sarcoma is a rare disease with limited reports of surgical resection.

Methods: This retrospective review included 41 patients with primary chest wall sarcoma who underwent chest wall resection and reconstruction from 2001 to 2015. The clinical, histologic, and surgical variables were collected and analyzed by univariate and multivariate Cox regression analyses for overall survival (OS) and recurrence-free survival (RFS).

Results: The OS rates at 5 and 10 years were 73% and 61%, respectively. The RFS rate at 10 years was 57.1%. Multivariate Cox regression analysis revealed old age (hazard ratio [HR], 5.16; 95% confidence interval [CI], 1.71-15.48) as a significant risk factor for death. A surgical resection margin distance of less than 1.5 cm (HR, 15.759; 95% CI, 1.78-139.46) and histologic grade III (HR, 28.36; 95% CI, 2.76-290.87) were independent risk factors for recurrence.

Conclusion: Long-term OS and RFS after the surgical resection of primary chest wall sarcoma were clinically acceptable.

Keywords: Chest wall; Sarcoma; Undifferentiated pleomorphic sarcoma.