Landscape of Noncoding RNA in Prostate Cancer

Trends Genet. 2019 Nov;35(11):840-851. doi: 10.1016/j.tig.2019.08.004. Epub 2019 Oct 14.

Abstract

The transcriptome of prostate cancer is highly heterogeneous, with noncoding transcripts being essential players. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are two unique classes of noncoding RNA drawing increasing attention. Biologically, they have intriguing properties with important regulatory functions. Clinically, they present as promising biomarkers and therapeutic targets. Recent advancements in technologies have opened up new directions for noncoding RNA research, which include RNA-protein interaction, RNA secondary structure, and spatial transcriptomics. Furthermore, recent work has also evaluated the clinical applications of these noncoding RNAs in noninvasive liquid biopsy and RNA-based therapies. In this review, we summarize recent findings on lncRNAs and circRNAs in prostate cancer, discuss their clinical utilities, and highlight these exciting areas of research.

Keywords: biomarkers; circular RNA; long noncoding RNA; noncoding RNA; prostate cancer; therapeutics.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor*
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / metabolism
  • RNA, Circular / genetics
  • RNA, Long Noncoding / chemistry
  • RNA, Long Noncoding / genetics*
  • RNA-Binding Proteins / metabolism
  • Structure-Activity Relationship

Substances

  • Biomarkers, Tumor
  • RNA, Circular
  • RNA, Long Noncoding
  • RNA-Binding Proteins