Abstract
In this work, we depleted glutathione (GSH) by releasing SO2 with internal stimulus GSH itself, and also selectively marked the cancer cells followed by release of anticancer drug using another orthogonal stimulus i.e., two-photon (TP) NIR light by a single naphthalene based chromophore (TP absorbance 77 GM and uncaging cross-section 21 GM). We demonstrated the improved therapeutic efficacy of chlorambucil by the stepwise dual stimuli approach and dual surveillance of both the drug uncaging process in real-time using in vitro studies.
MeSH terms
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Alkylating Agents / chemistry
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Alkylating Agents / pharmacology*
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Antineoplastic Agents, Alkylating / chemistry
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Antineoplastic Agents, Alkylating / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Chlorambucil / chemistry
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Chlorambucil / pharmacology*
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Drug Liberation
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Drug Resistance, Multiple / drug effects*
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Drug Resistance, Neoplasm / drug effects*
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Drug Screening Assays, Antitumor
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Glutathione / metabolism
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Humans
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Infrared Rays
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Molecular Structure
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Naphthalenes / chemistry
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Naphthalenes / pharmacology*
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Optical Imaging
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Photons*
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Sulfur Dioxide / metabolism
Substances
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Alkylating Agents
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Antineoplastic Agents, Alkylating
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Naphthalenes
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Sulfur Dioxide
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Chlorambucil
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naphthalene
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Glutathione