A new polyketide from the bark of Hypericum roeperianum Schimp. (Hypericaceae)

Nat Prod Res. 2021 Jul;35(14):2381-2387. doi: 10.1080/14786419.2019.1677655. Epub 2019 Oct 15.

Abstract

The isolation and spectroscopic data of a hitherto undescribed polyketide (1) from Hypericum roeperianum Schimp. (Hypericaceae) together with six known compounds (2-7) is herein reported. The structure elucidation is based on extensive 1D- and 2D-NMR, infrared, UV and MS experiments. The structures of the known compounds were confirmed by comparison of their spectroscopic data with those of similar reported compounds in the literature. Some of the isolated compounds had a significant activity against a panel of multidrug-resistant bacterial strains.Supplemental data for this article can be accessed at https://doi.org/10.1080/14786419.2019.1677655.

Keywords: Hypericum roeperianum; Hypericaceae; MDR; antibacterial; polyketide.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Hypericum / chemistry*
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Plant Bark / chemistry*
  • Polyketides / chemistry
  • Polyketides / isolation & purification*

Substances

  • Anti-Bacterial Agents
  • Polyketides