Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01

Xiao-Yang Han; Yi-Xuan Xie; Chao-Qun Wu; Hong-Lian Ai; Xin-Xiang Lei; Xiang-Jing Wang

doi:10.1002/cbdv.201900471

Novel Metabolites from the Endophytic Fungus Chaetomium subaffine L01

Chem Biodivers. 2019 Dec;16(12):e1900471. doi: 10.1002/cbdv.201900471. Epub 2019 Nov 12.

Authors

Xiao-Yang Han¹, Yi-Xuan Xie², Chao-Qun Wu², Hong-Lian Ai², Xin-Xiang Lei², Xiang-Jing Wang¹

Affiliations

¹ Key Laboratory of Agriculture Biological Functional Gene of Heilongjiang Provincial Education Committee, Northeast Agricultural University, Harbin, 150030, P. R. China.
² School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, P. R. China.

PMID: 31612620
DOI: 10.1002/cbdv.201900471

Abstract

One natural p-terphenyl glycoside, gliocladinin C, and two furano-polyene derivatives, chaetominins A and B, were isolated from potato endophytic fungus Chaetomium subaffine. The absolute configurations of these compounds were elucidated by HR-ESI-MS, NMR, the DP4+ probabilities and electronic circular dichroism (ECD) spectra. Furthermore, gliocladinin C and chaetominin A showed cytotoxic activity against two selected human tumor cell lines (Hep-2 and HepG-2).

Keywords: DP4+ probabilities; ECD, cytotoxicity; endophytic fungus; p-terphenyl.

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Chaetomium / chemistry
Chaetomium / metabolism*
Circular Dichroism
Humans
Magnetic Resonance Spectroscopy
Molecular Conformation
Terphenyl Compounds / chemistry*
Terphenyl Compounds / pharmacology

Substances

Antineoplastic Agents
Terphenyl Compounds

Abstract

MeSH terms

Substances

Grants and funding