Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate

Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01326-19. doi: 10.1128/AAC.01326-19. Print 2019 Dec 20.

Abstract

A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet(X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation. This report follows the recent study describing the identification of tet(X3) and tet(X4).

Keywords: Acinetobacter baumannii; tet(X5); tigecycline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / drug therapy
  • Acinetobacter Infections / microbiology
  • Acinetobacter baumannii / drug effects*
  • Acinetobacter baumannii / genetics*
  • Acinetobacter baumannii / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • China
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Gene Transfer, Horizontal
  • Genes, Bacterial*
  • Humans
  • Microbial Sensitivity Tests
  • Models, Genetic
  • Models, Molecular
  • Molecular Docking Simulation
  • Plasmids / genetics
  • Tetracycline Resistance / genetics
  • Tetracyclines / pharmacology
  • Tigecycline / pharmacology

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Tetracyclines
  • eravacycline
  • omadacycline
  • Tigecycline