Abstract
A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet(X5)-containing plasmid could only be transferred to A. baumannii via electrotransformation. This report follows the recent study describing the identification of tet(X3) and tet(X4).
Keywords:
Acinetobacter baumannii; tet(X5); tigecycline.
Copyright © 2019 American Society for Microbiology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / drug therapy
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / genetics*
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Acinetobacter baumannii / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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China
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Drug Resistance, Multiple, Bacterial / genetics*
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Gene Transfer, Horizontal
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Genes, Bacterial*
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Humans
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Microbial Sensitivity Tests
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Models, Genetic
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Models, Molecular
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Molecular Docking Simulation
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Plasmids / genetics
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Tetracycline Resistance / genetics
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Tetracyclines / pharmacology
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Tigecycline / pharmacology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Tetracyclines
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eravacycline
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omadacycline
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Tigecycline