An assessment was carried out of the anthropogenic enrichment of the chemical composition of the bottom sediments of water bodies situated in an area with an urban and industrial character (63.7% of the total area). The endorheic catchments of the water bodies studied are lithologically uniform with sandy formations accounting for more than 90% of the surface area. On the basis of geoaccumulation index values, it was found that the bottom sediments of the water bodies studied were contaminated with the following elements: Cd, Zn, S, As, Pb, Sr, Co, Cr, Cu, Ba, Ni, V, Be, in degrees ranging from moderate to extreme, with lower contamination (or absence of contamination) with the same elements being found in the formations present in the vicinity and in the substrate of the basins of water bodies. It was found that one consequence of the fact that these water bodies are located in urban and industrial areas is that there is anthropogenic enrichment of the chemical composition of bottom sediments with certain basic components (organic matter, Mn, Ca and P compounds) and trace elements: Cd, Zn, Pb, Sb, As, Cu and Co, Br, Ni, S, Be, Cs, Sr, V, Cr, Sc, Ba, U, Ce, Eu and Th, with virtually no enrichment of sediments with the other basic and trace components analysed (La, Rb, K2O, Nd, Sm, Na2O, Hf, SiO2, Zr).