Abstract
Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial and is still an effective antimalarial. Many researchers have reported ferrocene compounds as potent compounds useful as anticancer and antimalarial agents when hybridized with other pharmaceutical scaffolds. This review will be focused on compounds with ferrocene moieties that exhibit either an anticancer or antimalarial activity.
Keywords:
cancer; ferrocene compounds; ferroquine; malaria; organometallics.
MeSH terms
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Aminoquinolines / chemical synthesis
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Aminoquinolines / chemistry
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Aminoquinolines / pharmacology*
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Antimalarials / chemistry*
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Antimalarials / pharmacology
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Antimalarials / therapeutic use
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Antimalarials / toxicity
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Antineoplastic Agents / toxicity
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Chloroquine / chemistry
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Chloroquine / pharmacology*
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Drug Resistance, Neoplasm
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Drug Therapy, Combination
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Ferrous Compounds / chemical synthesis
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Ferrous Compounds / chemistry
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Ferrous Compounds / pharmacology*
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Humans
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Malaria / drug therapy
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Metallocenes / chemical synthesis
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Metallocenes / chemistry
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Metallocenes / pharmacology*
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Neoplasms / drug therapy
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Plasmodium falciparum / drug effects
Substances
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Aminoquinolines
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Antimalarials
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Antineoplastic Agents
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Ferrous Compounds
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Metallocenes
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Chloroquine
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ferroquine
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ferrocene