Textural Properties of Choriocapillaris on OCTA in Healed Inflammatory Choriocapillaropathies

Ophthalmic Surg Lasers Imaging Retina. 2019 Sep 1;50(9):566-572. doi: 10.3928/23258160-20190905-05.

Abstract

Background and objective: To evaluate the flow characteristics and textural properties of choriocapillaris (CC) on optical coherence tomography angiography in eyes with resolved inflammatory choriocapillaropathies and Vogt-Koyanagi-Harada (VKH) disease.

Patients and methods: A cohort of eyes with healed acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis (SC), and VKH disease were included. A 3 mm × 3 mm OCT angiogram of CC was acquired and graded for flow characteristics and textural properties.

Results: This study included 16 patients. Texture was heterogeneous in all eyes in the SC and VKH groups, and in four eyes (40%) in the APMPPE group. Most of the eyes with VKH disease had severe low flow, whereas most of the SC and APMPPE eyes demonstrated mild low flow. Heal duration had a strong negative correlation with severity of CC low flow and a weak, statistically nonsignificant correlation with texture heterogeneity.

Conclusion: Despite the resolution of active inflammation, partial CC hypoperfusion and texture disruptions persist for longer durations and may resolve in a time dependent manner. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:566-572.].

MeSH terms

  • Adult
  • Angiography
  • Choroid / physiopathology*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multifocal Choroiditis / diagnostic imaging
  • Multifocal Choroiditis / physiopathology*
  • Regional Blood Flow
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Uveomeningoencephalitic Syndrome / diagnostic imaging
  • Uveomeningoencephalitic Syndrome / physiopathology*
  • White Dot Syndromes / diagnostic imaging
  • White Dot Syndromes / physiopathology*