Objective: To study the innervation of the major sublingual gland by means of immunohistochemistry.
Design: Bioptic and autoptic specimens of the major sublingual gland of humans were examined for the presence of immunoreactivity to tyrosine hydroxylase and dopamine-β-hydroxylase, on one hand, and choline acetyltransferase, on the other, to indicate adrenergic and cholinergic nerves, respectively.
Results: Acini and ducts were supplied by both divisions of the autonomic nervous system.
Conclusions: Mucous and seromucous cells of the human major sublingual glands may respond with secretion not only to parasympathetic activity but also to sympathetic activity. The major sublingual gland is therefore a potential contributor to the mucin secretion recently reported in the literature in response to high sympathetic activity during physical exercise.
Keywords: Choline acetyltransferase; Dopamine beta-hydroxylase; Human major sublingual gland; Immunohistochemistry; Tyrosine hydroxylase.
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