The miR-145 rs353291 C allele increases susceptibility to atherosclerosis

Front Biosci (Landmark Ed). 2020 Jan 1;25(3):577-592. doi: 10.2741/4822.

Abstract

Atherosclerosis (AS) is one of the leading causes of death, with variable frequencies in different populations. To this end, we examined whether AS is associated with the miR-145 rs353291 polymorphism and specific rs353291 alleles. The distribution of the rs353291 C allele and CC genotypes was significantly higher in AS patients than in controls. Compared to individuals with the rs353291 TT genotype, carriers of the rs353291 C allele showed a significant increase in the plasma levels of sCD40L, IL-6 and MCP-1 and a decrease in miR-145 expression. After ox-LDL administration, the peripheral blood mononuclear cells (PBMCs) of rs353291 C allele carriers showed significantly increased CD40 and MCP-1 expression compared with those of individuals with the rs353291 TT genotype. These data suggest that the rs353291 C allele may increase susceptibility to atherosclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Atherosclerosis / genetics*
  • CD40 Antigens / blood
  • CD40 Ligand / blood
  • Cells, Cultured
  • Chemokine CCL2 / blood
  • Female
  • Gene Expression
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Interleukin-6 / blood
  • Leukocytes, Mononuclear / drug effects
  • Leukocytes, Mononuclear / metabolism
  • Lipoproteins, LDL / pharmacology
  • Male
  • MicroRNAs / genetics*
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • THP-1 Cells

Substances

  • CCL2 protein, human
  • CD40 Antigens
  • Chemokine CCL2
  • Interleukin-6
  • Lipoproteins, LDL
  • MIRN145 microRNA, human
  • MicroRNAs
  • oxidized low density lipoprotein
  • CD40 Ligand