Pancreatic β-cells express major histocompatibility complex class II: Do diabetic β-cells have the capacity of antigen-presenting cells?

J Diabetes Investig. 2020 Mar;11(2):281-283. doi: 10.1111/jdi.13155. Epub 2019 Nov 6.

Abstract

Russell et al. showed that major histocompatibility complex class II is expressed in pancreatic β-cells by a highly accurate method called transcriptome analysis. Pancreatic β-cells might have the capacity as antigen-presenting cells.

MeSH terms

  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / metabolism
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / metabolism
  • Histocompatibility Antigens Class II / immunology*
  • Histocompatibility Antigens Class II / metabolism
  • Humans
  • Insulin-Secreting Cells / immunology*
  • Insulin-Secreting Cells / metabolism

Substances

  • Histocompatibility Antigens Class II