One of the current challenges in ultrasound imaging is achieving higher frame rates, particularly in cardiac applications, where tracking the heart motion and other rapid events can provide potential valuable diagnostic information. The main drawback of ultrasound high-frame-rate strategies is that usually they partly sacrifice image quality in order to speed up the acquisition time. In particular, multi-line transmission (MLT), which consists in transmitting multiple ultrasound beams simultaneously in different directions, has been proven able to improve frame rates in echocardiography, unfortunately generating artifacts due to inter-beam crosstalk interferences. This work investigates the possibility to effectively suppress crosstalk artifacts in MLT while improving image quality by applying beamforming techniques based on backscattered signals spatial coherence. Several coherence-based algorithms (i.e., short-lag filtered-delay multiply and sum beamforming, coherence and generalized coherence factor, phase and sign coherence, and nonlinear beamforming with p th root compression) are implemented and compared, and their performance trends are evaluated when varying their design parameters. Indeed, experimental results of phantom and in vivo cardiac acquisitions demonstrate that this class of algorithms can provide significant benefits compared with delay and sum, well-suppressing artifacts (up to 48.5-dB lower crosstalk), and increasing image resolution (by up to 46.3%) and contrast (by up to 30 dB in terms of contrast ratio and 12.6% for generalized contrast-to-noise ratio) at the same time.