Vancomycin is a widely used antibiotic in hemodialysis patients. The main complications include renal toxicity and skin lesions. Herein, we report the case of a 29-year-old hemodialysis patient who presented a bullous pruriginous dermatosis after vancomycin treatment. A skin biopsy revealed a linear IgA bullous dermatosis (LABD). This is a rare form of dermatosis and is either idiopathic or more likely vancomycin-induced. Similarities in the molecular structure of vancomycin and epidermal basement membrane glycoproteins could explain the auto-immune response. The overall prognosis after drug discontinuation and dermocorticoid treatment was good.
Keywords: dialysis; skin; toxicity; vancomycin.
© 2019 International Society for Hemodialysis.