SIVcpz cross-species transmission and viral evolution toward HIV-1 in a humanized mouse model

J Med Primatol. 2020 Feb;49(1):40-43. doi: 10.1111/jmp.12440. Epub 2019 Oct 1.

Abstract

HIV-1 evolved from its progenitor SIV strains, but details are lacking on its adaptation to the human host. We followed the evolution of SIVcpz in humanized mice to mimic cross-species transmission. Increasing viral loads, CD4+ T-cell decline, and non-synonymous mutations were seen in the entire genome reflecting viral adaptation.

Keywords: SIVcpz evolution into HIV-1; SIVcpz pathogenesis in humanized mice; cross-species transmission of SIV; modeling SIV evolution using humanized mice; viral evolution of SIVcpzEK505 into HIV-1.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Biological Evolution
  • CD4 Lymphocyte Count*
  • Evolution, Molecular*
  • Genome, Viral*
  • HIV Infections / veterinary
  • HIV Infections / virology
  • HIV-1 / genetics
  • HIV-1 / physiology*
  • Mice
  • Mice, Transgenic
  • Simian Acquired Immunodeficiency Syndrome / virology
  • Simian Immunodeficiency Virus / genetics
  • Simian Immunodeficiency Virus / physiology*
  • Viral Load*

Associated data

  • GENBANK/DQ373065.1