To explore the clinical characters, treatment and prognosis for pediatric optic pathway gliomas (OPGs). Methods: A total of 26 patients with OPGs, who were diagnosed and treated at Neurosurgery of Xiangya Hospital of Central South University between June 2010 and November 2017, were retrospectively reviewed, and their average age was 5.5 years old. The influential factors for patients' progression-free survival (PFS) and overall survival (OS) were analyzed. Results: All patients were classified into Type II and Type III based on Dodge classification and received surgery treatment. Vision was improved after surgery in 20 patients. Twenty-four patients (92.3%) were continually followed up, and 14 patients (58.3%) received post-radiation treatment. Twenty-one patients were still alive and 15 patients' symptoms were not progressed. The PFS and OS in patients received radiation therapy were better than those without radiation therapy (PFS: P<0.01; OS: P<0.05). The postoperative visual prognosis might be related to the choice of surgical approach. Conclusion: Treatment of children with OPGs should include surgery and postoperative radiotherapy. The eyesight protection in surgery is as important as tumor resection.
目的：探讨儿童视路胶质瘤(optic pathway gliomas，OPGs)的临床特点、治疗方法及预后情况。方法：回顾性分析湘雅医院神经外科自2010年6月至2017年11月收治的26例OPGs患儿的临床及随访资料，平均年龄为5岁6个月，分析视力、总生存及无进展生存的影响因素。结果：本组患儿均为DodgeII型和III型，且接受肿瘤切除手术，术后患儿视力好转20例。随访了24例(92.3%)患儿，14例接受放射治疗，总生存21例，无进展生存15例。接受放射治疗患儿无进展生存及总生存均优于未接受放射治疗患儿，差异均具有统计学意义(无进展生存：P<0.01；总生存：P<0.05)；患儿术后视力预后与手术入路的选择相关。结论：儿童视路胶质瘤的治疗应包括手术与术后放射治疗。为保证患儿术后生活质量，保护视力与切除肿瘤同样重要。.