Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer

Hsieh-Chih Tsai; Hsiao-Ying Chou; Shun-Hao Chuang; Juin-Yih Lai; Yi-Shu Chen; Yu-Han Wen; Lu-Yi Yu; Chun-Liang Lo

doi:10.3390/polym11101592

Preparation of Immunotherapy Liposomal-Loaded Thermal-Responsive Hydrogel Carrier in the Local Treatment of Breast Cancer

Polymers (Basel). 2019 Sep 29;11(10):1592. doi: 10.3390/polym11101592.

Authors

Hsieh-Chih Tsai^{1

2}, Hsiao-Ying Chou³, Shun-Hao Chuang⁴, Juin-Yih Lai^{5

6

7}, Yi-Shu Chen⁸, Yu-Han Wen⁹, Lu-Yi Yu¹⁰, Chun-Liang Lo¹¹

Affiliations

¹ Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. h.c.tsai@mail.ntust.edu.tw.
² Advanced Membrane Materials Center, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. h.c.tsai@mail.ntust.edu.tw.
³ Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. wherelove8@gmail.com.
⁴ Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. smallwhite90301@gmail.com.
⁵ Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. jylai@cycu.edu.tw.
⁶ Advanced Membrane Materials Center, National Taiwan University of Science and Technology, Taipei 10607, Taiwan. jylai@cycu.edu.tw.
⁷ R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan 32023, Taiwan. jylai@cycu.edu.tw.
⁸ Department of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan. kerry840726@gmail.com.
⁹ Department of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan. qooaz0815@hotmail.com.
¹⁰ Department of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan. smallfish410048@hotmail.com.
¹¹ Department of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan. cllo@ym.edu.tw.

Abstract

To reduce the side effects of immune drugs and the sustainable release of immune drugs on local parts, we have designed an injectable thermal-sensitive hydrogel containing an imiquimod-loaded liposome system. In the extracellular environment of tumor tissues (pH 6.4), 50% of the drug was released from the carrier, which could be a result of the morphological changes of the liposomal microstructure in the acidic environment. According to the results in animals, the drug-containing liposomes combined with hydrogel can be effectively applied in breast cancer therapy to delay the growth of tumors as well as to dramatically reduce the death rate of mice.

Keywords: immunotherapy; injectable; liposomes; temperature-sensitive hydrogel.

Grants and funding

NTUST-NYMU-106-01/The authors would like to thank the Natioanl Taiwan University of Science and Technology and National Yang Ming University (NTUST-NYMU-106-01) for providing the financial support.