Manganese neurotoxicity: nano-oxide compensates for ion-damage in mammals

Biomater Sci. 2019 Nov 1;7(11):4491-4502. doi: 10.1039/c9bm01039d. Epub 2019 Sep 30.

Abstract

Here, we have compared the behavioral neurotoxicity of a manganese nanoformulation (citrate functionalized Mn3O4 nanoparticles; C-Mn3O4 NPs) with that of the well-known neurotoxicant, ionic Mn, in an animal model. We found that mice administered with C-Mn3O4 NPs showed no signs of a neurobehavioral disorder, but the NPs instead ameliorated Mn-induced neurotoxicity (Parkinson's-like syndrome) through the chelation of excess Mn ions and subsequent reduction of oxidative damage.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Disease Models, Animal*
  • Hippocampus / drug effects*
  • Hippocampus / metabolism
  • Hippocampus / pathology
  • Manganese Compounds / administration & dosage
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Nanoparticles / administration & dosage
  • Nanoparticles / toxicity*
  • Neurons / drug effects*
  • Neurons / metabolism
  • Neurons / pathology
  • Oxidation-Reduction
  • Oxides / administration & dosage
  • Oxides / toxicity*

Substances

  • Manganese Compounds
  • Oxides
  • manganese oxide