The master knot of Henry refers to a narrow space located between the anatomical crossover of the flexor hallucis longus and flexor digitorum longus tendons. This small space is prone to "intersection syndrome," as a result of tendinosis, tenosynovitis, and tears of the aforementioned tendons at the knot of Henry. The aim of this educational review is to detail the anatomy of the knot of Henry, including common variations in the tendon position and orientation. These complex interconnections can affect the outcome of surgical intervention if not appreciated at the time of treatment. We will also provide an overview of the common and rarer pathologies related to the knot of Henry. The aim of the present review is to make radiologists more aware of pathologies in this region, which are not routinely seen in daily practice.
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