[Amiodarone-induced optic neuropathy: A rare side effect]

Rev Med Interne. 2019 Dec;40(12):826-830. doi: 10.1016/j.revmed.2019.09.001. Epub 2019 Sep 24.
[Article in French]

Abstract

Introduction: The diagnosis of bilateral papilledema implies emergency medical care to look for intracranial hypertension and arteritic ischemic neuropathy. However, other causes must also be mentioned, including drugs. Too often underrated because of their usual benignity, drug side ophthalmological effects can be severe and are typically bilateral.

Case report: An 80-year-old woman was hospitalized for bilateral papilledema, predominantly in the left eye, with lowered visual acuity. After ruling out intracranial hypertension, arteritic ischemic optic neuropathy, non-arteritic, and inflammatory bilateral papilledema, the diagnosis was toxic optic neuropathy.

Conclusion: Bilateral edematous optic neuropathy is a known side effect of amiodarone, uncommon but to be known because of the large number of patients benefiting from this treatment.

Keywords: Amiodarone; Neuropathie optique; Optic neuropathy; Papillary disease; Toxicity; Toxicité; Œdème papillaire.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Amiodarone / adverse effects*
  • Anti-Arrhythmia Agents / adverse effects*
  • Female
  • Humans
  • Iatrogenic Disease
  • Optic Nerve Diseases / chemically induced*
  • Optic Nerve Diseases / diagnosis
  • Papilledema / chemically induced
  • Papilledema / diagnosis
  • Vision Disorders / chemically induced
  • Vision Disorders / diagnosis
  • Visual Acuity / drug effects

Substances

  • Anti-Arrhythmia Agents
  • Amiodarone