Very Short Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Patients With High Bleeding Risk: Insight From the STOPDAPT-2 Trial

Hirotoshi Watanabe; Takenori Domei; Takeshi Morimoto; Masahiro Natsuaki; Hiroki Shiomi; Toshiaki Toyota; Masanobu Ohya; Satoru Suwa; Kensuke Takagi; Mamoru Nanasato; Yoshiki Hata; Masahiro Yagi; Nobuhiro Suematsu; Takafumi Yokomatsu; Itaru Takamisawa; Masayuki Doi; Toshiyuki Noda; Hideki Okayama; Yoshitane Seino; Tomohisa Tada; Hiroki Sakamoto; Kiyoshi Hibi; Mitsuru Abe; Kazuya Kawai; Koichi Nakao; Kenji Ando; Kengo Tanabe; Yuji Ikari; Keiichi Igarashi Hanaoka; Yoshihiro Morino; Ken Kozuma; Kazushige Kadota; Yutaka Furukawa; Yoshihisa Nakagawa; Takeshi Kimura; STOPDAPT-2 Investigators

doi:10.1161/CIRCULATIONAHA.119.043613

Very Short Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Patients With High Bleeding Risk: Insight From the STOPDAPT-2 Trial

Circulation. 2019 Dec 3;140(23):1957-1959. doi: 10.1161/CIRCULATIONAHA.119.043613. Epub 2019 Sep 27.

Authors

Hirotoshi Watanabe¹, Takenori Domei², Takeshi Morimoto³, Masahiro Natsuaki⁴, Hiroki Shiomi¹, Toshiaki Toyota⁵, Masanobu Ohya⁶, Satoru Suwa⁷, Kensuke Takagi⁸, Mamoru Nanasato⁹, Yoshiki Hata¹⁰, Masahiro Yagi¹¹, Nobuhiro Suematsu¹², Takafumi Yokomatsu¹³, Itaru Takamisawa⁹, Masayuki Doi¹⁴, Toshiyuki Noda¹⁵, Hideki Okayama¹⁶, Yoshitane Seino¹⁷, Tomohisa Tada¹⁸, Hiroki Sakamoto¹⁸, Kiyoshi Hibi¹⁹, Mitsuru Abe²⁰, Kazuya Kawai²¹, Koichi Nakao²², Kenji Ando², Kengo Tanabe²³, Yuji Ikari²⁴, Keiichi Igarashi Hanaoka²⁵, Yoshihiro Morino²⁶, Ken Kozuma²⁷, Kazushige Kadota⁶, Yutaka Furukawa⁵, Yoshihisa Nakagawa²⁸, Takeshi Kimura¹; STOPDAPT-2 Investigators

Affiliations

¹ Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan (H.W., H. Shiomi, T.K.).
² Department of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan (T.D., K.A.).
³ Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan (T.M.).
⁴ Department of Cardiovascular Medicine, Saga University, Japan (M.N.).
⁵ Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Japan (T. Toyota, Y.F.).
⁶ Department of Cardiology, Kurashiki Central Hospital, Japan (M.O., K. Kadota).
⁷ Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Japan (S.S.).
⁸ Department of Cardiology, Ogaki Municipal Hospital, Japan (K. Takagi).
⁹ Department of Cardiology, Sakakibara Heart Institute, Fuchu, Japan (M.N., I.T.).
¹⁰ Department of Cardiology, Minamino Cardiovascular Hospital, Hachioji, Japan (Y.H.).
¹¹ Department of Cardiology, Sendai Cardiovascular Center, Japan (M.Y.).
¹² Department of Cardiology, Saiseikai Fukuoka General Hospital, Japan (N.S.).
¹³ Department of Cardiology, Mitsubishi Kyoto Hospital, Kyoto, Japan (T.Y.).
¹⁴ Department of Cardiology, Kagawa Prefectural Central Hospital, Takamatsu, Japan (M.D.).
¹⁵ Department of Cardiology, Gifu Prefectural General Medical Center, Japan (T.N.).
¹⁶ Department of Cardiology, Ehime Prefectural Central Hospital, Matsuyama, Japan (H.O.).
¹⁷ Department of Cardiology, Hoshi General Hospital, Koriyama, Japan (Y.S.).
¹⁸ Department of Cardiology, Shizuoka General Hospital, Japan (T. Tada, H. Sakamoto).
¹⁹ Division of Cardiology, Yokohama City University Medical Center, Japan (K.H.).
²⁰ Department of Cardiology, National Hospital Organization Kyoto Medical Center, Japan (M.A.).
²¹ Department of Cardiology, Chikamori Hospital, Kochi, Japan (K. Kawai).
²² Division of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Japan (K.N.).
²³ Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan (K. Tanabe).
²⁴ Department of Cardiology, Tokai University Hospital, Isehara, Japan (Y.I.).
²⁵ Hanaoka Seishu Memorial Cardiovascular Clinic, Sapporo, Japan (K.I.H.).
²⁶ Department of Cardiology, Iwate Medical University Hospital, Morioka, Japan (Y.M.).
²⁷ Department of Cardiology, Teikyo University Hospital, Tokyo, Japan (K. Kozuma).
²⁸ Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan (Y.N.).

PMID: 31560216
DOI: 10.1161/CIRCULATIONAHA.119.043613

No abstract available

Keywords: hemorrhage; percutaneous coronary intervention; platelet aggregation inhibitors; stents; thrombosis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aspirin / administration & dosage
Aspirin / adverse effects
Aspirin / therapeutic use*
Chromium Alloys
Clopidogrel / administration & dosage
Clopidogrel / adverse effects
Clopidogrel / therapeutic use*
Coronary Restenosis / epidemiology
Coronary Restenosis / etiology
Drug Administration Schedule
Drug Therapy, Combination
Drug-Eluting Stents
Everolimus / administration & dosage
Everolimus / therapeutic use*
Female
Hemorrhage / chemically induced
Hemorrhage / prevention & control*
Humans
Incidence
Japan / epidemiology
Male
Middle Aged
Multicenter Studies as Topic / statistics & numerical data*
Myocardial Infarction / epidemiology
Myocardial Infarction / etiology
Platelet Aggregation Inhibitors / administration & dosage
Platelet Aggregation Inhibitors / adverse effects
Platelet Aggregation Inhibitors / therapeutic use*
Postoperative Complications / epidemiology
Postoperative Complications / etiology
Postoperative Complications / prevention & control
Proportional Hazards Models
Randomized Controlled Trials as Topic / statistics & numerical data*
Single-Blind Method
Stroke / epidemiology
Stroke / etiology

Substances

Chromium Alloys
Platelet Aggregation Inhibitors
Everolimus
Clopidogrel
Aspirin