Complete Genome Sequence of Herpes Simplex Virus 1 Strain McKrae

Xiaoli Jiao; Hongyan Sui; Christopher Lyons; Bao Tran; Brad T Sherman; Tomozumi Imamichi

doi:10.1128/MRA.00993-19

Complete Genome Sequence of Herpes Simplex Virus 1 Strain McKrae

Microbiol Resour Announc. 2019 Sep 26;8(39):e00993-19. doi: 10.1128/MRA.00993-19.

Authors

Xiaoli Jiao^#¹, Hongyan Sui^#¹, Christopher Lyons², Bao Tran², Brad T Sherman¹, Tomozumi Imamichi³

Affiliations

¹ Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
² Sequencing Facility, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
³ Laboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA timamichi@mail.nih.gov.

^# Contributed equally.

Abstract

Herpes simplex virus 1 (HSV-1) strain McKrae is highly virulent and relatively neuroinvasive in animal models compared with other wild-type HSV-1 strains. To identify the genetic determinants that lead to the unique phenotypes of the McKrae strain, we sequenced its genome with PacBio single-molecule real-time (SMRT) technology and resolved the complete sequence.

Abstract

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