Chemical and enzymatic synthesis of the alginate sugar nucleotide building block: GDP-d-mannuronic acid

Carbohydr Res. 2019 Nov 1:485:107819. doi: 10.1016/j.carres.2019.107819. Epub 2019 Sep 17.

Authors

Laura Beswick¹, Sanaz Ahmadipour¹, Jonathan P Dolan¹, Martin Rejzek¹, Robert A Field¹, Gavin J Miller²

Affiliations

¹ Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK.
² Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: g.j.miller@keele.ac.uk.

PMID: 31557683
DOI: 10.1016/j.carres.2019.107819

No abstract available

Keywords: Alginate; Glycosyl-1-phosphate; Mannuronate; Pyrophosphorylation; Sugar nucleotide.

MeSH terms

Alginates / chemistry*
Carbohydrate Dehydrogenases / metabolism*
Chemistry Techniques, Synthetic
Guanosine Diphosphate / chemistry*
Hexuronic Acids / chemical synthesis*
Hexuronic Acids / chemistry*
Pseudomonas aeruginosa / enzymology
Recombinant Proteins / metabolism

Substances

Alginates
Hexuronic Acids
Recombinant Proteins
Guanosine Diphosphate
mannuronic acid
Carbohydrate Dehydrogenases
GDPmannose dehydrogenase

Grants and funding

BBS/E/J/000C0618/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom