Abstract
A chemoenzymatic reduction of citreorosein by the NADPH-dependent polyhydroxyanthracene reductase from Cochliobolus lunatus or MdpC from Aspergillus nidulans in the presence of Na2S2O4 gave access to putative biosynthetic intermediates, (R)-3,8,9,10-tetrahydroxy-6-(hydroxymethyl)-3,4-dihydroanthracene-1(2H)-one and its oxidized form, (R)-3,4-dihydrocitreorosein. Herein, we discuss the implications of these results towards the (bio)synthesis of aloe-emodin and (+)-rugulosin C in fungi.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anthraquinones / chemistry
-
Anthraquinones / metabolism*
-
Ascomycota / enzymology
-
Fungal Proteins / chemistry
-
Fungal Proteins / metabolism*
-
Molecular Structure
-
Oxidation-Reduction
-
Oxidoreductases Acting on CH-CH Group Donors / chemistry
-
Oxidoreductases Acting on CH-CH Group Donors / metabolism*
Substances
-
Anthraquinones
-
Fungal Proteins
-
rugulosin C
-
tetrahydroxynaphthalene reductase
-
Oxidoreductases Acting on CH-CH Group Donors
-
citreorosein