Hidradenitis suppurativa (HS) is a chronic and recurrent inflammatory disease characterized by the presence of painful and deep inflammatory lesions usually located in intertriginous areas. It rarely occurs in children, especially in prepubertal age. Treatment for HS in this age group is challenging considering the scant data available and the risk of adverse effects in younger patients. We report the case of a 10-year-old girl with Hurley III HS, refractory to multiple topical and systemic therapies. After introducing adalimumab, there was significant improvement of the skin lesions and therefore in the child's quality of life.