Mouse Models as Resources for Studying Infectious Diseases

Sanjay Sarkar; Mark T Heise

doi:10.1016/j.clinthera.2019.08.010

Mouse Models as Resources for Studying Infectious Diseases

Clin Ther. 2019 Oct;41(10):1912-1922. doi: 10.1016/j.clinthera.2019.08.010. Epub 2019 Sep 18.

Authors

Sanjay Sarkar¹, Mark T Heise²

Affiliations

¹ Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
² Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address: mark_heisem@med.unc.edu.

Abstract

Mouse models are important tools both for studying the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against a wide variety of human pathogens. The use of genetically defined inbred mouse strains, humanized mice, and gene knockout mice has allowed the research community to explore how pathogens cause disease, define the role of specific host genes in either controlling or promoting disease, and identify potential targets for the prevention or treatment of a wide range of infectious agents. This review discusses several of the most commonly used mouse model systems, as well as new resources such as the Collaborative Cross as models for studying infectious diseases.

Keywords: genetics; host/pathogen interactions; infectious diseases; mouse models.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Communicable Diseases*
Disease Models, Animal*
Humans
Mice
Mice, Inbred Strains
Xenograft Model Antitumor Assays

Abstract

Publication types

MeSH terms

Grants and funding