Application of FTIR Method for the Assessment of Immobilization of Active Substances in the Matrix of Biomedical Materials

Dorota Kowalczuk; Monika Pitucha

doi:10.3390/ma12182972

Application of FTIR Method for the Assessment of Immobilization of Active Substances in the Matrix of Biomedical Materials

Materials (Basel). 2019 Sep 13;12(18):2972. doi: 10.3390/ma12182972.

Authors

Dorota Kowalczuk¹, Monika Pitucha²

Affiliations

¹ Chair and Department of Medicinal Chemistry, Faculty of Pharmacy with Division of Medical Analytics, the Medical University of Lublin, 20-090 Lublin, Poland. dorota.kowalczuk@umlub.pl.
² Independent Radiopharmacy Unit, Faculty of Pharmacy with Division of Medical Analytics, the Medical University of Lublin, 20-093 Lublin, Poland.

Abstract

Background: The purpose of the study was to demonstrate the usefulness of the Fourier transform infrared spectroscopy (FTIR) method for the evaluation of the modification process of biomaterials with the participation of active substances.

Methods: Modified catheter samples were prepared by activating the matrix with an acid, iodine, or bromine, and then immobilizing the active molecules. To carry out the modification process, the Fourier transform infrared-attenuated total reflectance (FTIR-ATR) method was used.

Results: FTIR analysis indicated the presence of the immobilized substances in the catheter matrix and site-specific reactions.

Conclusion: We surmise that the infrared spectroscopic technique is an ideal tool for the assessment of the drug immobilization and the changes occurring in the course of the modification process.

Keywords: FTIR analysis; biomaterial characterization; biomaterial modification; immobilization.