The possible mechanisms of the effects of IRX3 gene on body weight: an overview

Maryam Gholamalizadeh; Alirea Mosavi Jarrahi; Mohammad Esmail Akbari; Shahla Rezaei; Saeid Doaei; Zohreh Mokhtari; Abbas Torki

doi:10.5114/amsad.2019.87545

The possible mechanisms of the effects of IRX3 gene on body weight: an overview

Arch Med Sci Atheroscler Dis. 2019 Aug 27:4:e225-e230. doi: 10.5114/amsad.2019.87545. eCollection 2019.

Authors

Maryam Gholamalizadeh¹, Alirea Mosavi Jarrahi², Mohammad Esmail Akbari³, Shahla Rezaei⁴, Saeid Doaei⁵, Zohreh Mokhtari⁶, Abbas Torki⁷

Affiliations

¹ Students' Research Committee, Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Faculty of Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Students' Research Committee, PhD student in Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
⁵ Research Center of Health and Environment, Guilan University of Medical Sciences, Rasht, Iran.
⁶ Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁷ Department of Nutrition, Faculty of Nutrition Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Introduction: Recent studies reported that FTO exert its effects on body weight through change the expression IRX3. The aim of this study was investigation of the possible mechanisms of the effects of IRX3 gene on obesity.

Material and methods: The present review was carried out using keywords such as polymorphism and/or obesity and/or BMI and/or IRX3 gene and/or Iroquois homeobox protein 3. Databases including PubMed, Science Direct, web of sciences, Scopus, and Cochran databases were used to collect all related articles published from 2000 to 2019.

Results: Based on this review, there are some evidences on the association between the IRX3 polymorphisms and the IRX3 expression level with body weight. In some studies, the up-regulation of IRX3 expression was related to increased body weight, while in some other studies down-regulation of IRX3 expression was related to obesity.

Conclusions: This review investigated the probable mechanisms of the effects of the IRX3 gene on obesity. Studies in this are limited and reported contradictory results. Further studies are required to evaluate the role of IRX3 gene in the associations between genes, diet, and obesity.

Keywords: IRX3; body mass index; diet; iroquois-related homeobox 3; obesity.