Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(ii) complex inducing apoptosis in hepatocellular carcinoma cells

Junshuai Zhang; Jiyong Hu; Kun Peng; Wei Song; Shuangcheng Zhi; Endian Yang; Jin'an Zhao; Hongwei Hou

doi:10.1039/c9cc05995d

Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(ii) complex inducing apoptosis in hepatocellular carcinoma cells

Chem Commun (Camb). 2019 Oct 1;55(79):11944-11947. doi: 10.1039/c9cc05995d.

Authors

Junshuai Zhang¹, Jiyong Hu¹, Kun Peng², Wei Song¹, Shuangcheng Zhi¹, Endian Yang¹, Jin'an Zhao³, Hongwei Hou⁴

Affiliations

¹ College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China.
² Institute of Inorganic Chemistry, University of Wuerzburg, Bavaria 97074, Germany.
³ College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China and College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China. zjinan@zzu.edu.cn.
⁴ College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China. zjinan@zzu.edu.cn.

PMID: 31531457
DOI: 10.1039/c9cc05995d

Abstract

A novel hexanuclear copper(ii)-based complex, [Cu6(tpbb)2(NO3)12] (1), was synthesized, which shows potent cytotoxicity to hepatoma carcinoma cells by inducing apoptosis and apoptosis-related processes. Furthermore, mechanistic investigations based on proteomes revealed that the induced apoptosis was mediated by acting on several targets and multiple pathways in a pleiotropic way.

MeSH terms

Apoptosis / drug effects*
Carcinoma, Hepatocellular / drug therapy*
Carcinoma, Hepatocellular / pathology
Cell Line, Tumor
Cell Membrane Permeability
Cell Survival / drug effects
Coordination Complexes / chemistry*
Coordination Complexes / pharmacology
Copper / chemistry*
DNA Damage / drug effects
Drug Design
Humans
Ligands
Liver Neoplasms / drug therapy*
Liver Neoplasms / pathology
Molecular Docking Simulation
Structure-Activity Relationship

Substances

Coordination Complexes
Ligands
Copper