The complete genome sequence of the lumpy skin disease virus vaccine Herbivac LS reveals a mutation in the superoxide dismutase gene homolog

Nicola Douglass; Anelda Van Der Walt; Ruzaiq Omar; Henry Munyanduki; Anna-Lise Williamson

doi:10.1007/s00705-019-04405-8

The complete genome sequence of the lumpy skin disease virus vaccine Herbivac LS reveals a mutation in the superoxide dismutase gene homolog

Arch Virol. 2019 Dec;164(12):3107-3109. doi: 10.1007/s00705-019-04405-8. Epub 2019 Sep 16.

Authors

Nicola Douglass¹, Anelda Van Der Walt^{2

3}, Ruzaiq Omar⁴, Henry Munyanduki⁴, Anna-Lise Williamson⁴

Affiliations

¹ Department of Pathology, Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, University of Cape Town, Observatory, 7925, South Africa. Niki.Douglass@uct.ac.za.
² Central Analytic Facility (CAF), University of Stellenbosch, JC Smuts Building, Van der Bijl Str, Stellenbosch, 7600, South Africa.
³ Talarify, Registration no 2015/014921/07, PO Box 293, Kleinmond, 7195, South Africa.
⁴ Department of Pathology, Institute of Infectious Disease and Molecular Medicine and Division of Medical Virology, University of Cape Town, Observatory, 7925, South Africa.

PMID: 31529221
DOI: 10.1007/s00705-019-04405-8

Abstract

The lumpy skin disease virus (LSDV) vaccine, Herbivac LS, batch 008, was sequenced and found to differ from the Neethling vaccine strain in the locus encoding a superoxide dismutase (SOD) homolog. The presence of a SOD homolog, be it full-length (as in Herbivac LS) or truncated (as in Neethling) may affect vaccine immunogenicity.

MeSH terms

Animals
Cattle
Genome Size
Lumpy skin disease virus / classification
Lumpy skin disease virus / enzymology
Lumpy skin disease virus / genetics*
Mutation
Superoxide Dismutase / genetics*
Viral Proteins / genetics
Viral Vaccines / genetics
Whole Genome Sequencing / methods*

Substances

Viral Proteins
Viral Vaccines
Superoxide Dismutase

Abstract

MeSH terms

Substances

Grants and funding