Primary amides to amines or nitriles: a dual role by a single catalyst

Chem Commun (Camb). 2019 Oct 1;55(79):11868-11871. doi: 10.1039/c9cc05856g.

Abstract

We report a manganese-catalyzed hydrosilylative reduction of various primary amides to amines (25 examples). On simple modification of the reaction conditions such as in the presence of a catalytic amount of secondary amide, the same catalyst can transform the primary amides into intermediate nitrile compounds (16 examples) in excellent yields. This is the first example where such a controlled catalytic transformation of primary amides to amines or nitriles with a single catalyst has been demonstrated.