Radiation induced lung injury (RILI) is a serious complication in patients received thoracic radiotherapy. The main clinical symptom of RILI includes short of breath, low fever and cough, seriously affect the survival of patients. How to better prevent and treat RILI is an urgent problem. Target theory, cytokine theory, free radical theory, and vascular endothelial cell damage theory are the main mechanisms of RILI. Among them, reactive oxygen species (ROS) produced during radiotherapy can induce tissue damage throughout the course of RILI, and have a direct effect on both radiation pneumonitis and radiation-induced lung fibrosis. Anti-oxygen therapy including thiol compounds, antioxidant enzymes, and plant antioxidants have been applied in the prevention and treatment of RILI. This article reviews the research and application of antioxidant therapy in RILI. .
【中文题目：抗氧化治疗在放射性肺损伤中的研究进展】 【中文摘要：放射性肺损伤（radiation induced lung injury, RILI）是临床上胸部肿瘤患者放疗后发生的严重并发症，主要表现为气短、低热、咳嗽等，严重影响患者生存，如何更好地防治RILI是亟待探索的问题。RILI的发生机制主要包括靶细胞学说、细胞因子学说、自由基学说、血管内皮细胞损伤学说。其中放疗产生的活性氧（reactive oxygen species, ROS）对组织的损伤贯穿整个RILI病程，对放射性肺炎和放射性肺纤维化均具有直接促进作用。包括巯基化合物、抗氧化酶、植物抗氧化剂等在内的治疗手段已被用于防治RILI，本文即就抗氧化治疗在RILI中的研究与应用作一综述。 】 【中文关键词：活性氧；抗氧化治疗；放射性肺损伤；放疗防护】.
Keywords: Anti-oxygen therapy; Radiation protection; Radiation-induced lung injury; Reactive oxygen species.