Design strategies for programmable oligonucleotide nanotherapeutics

Drug Discov Today. 2020 Jan;25(1):73-88. doi: 10.1016/j.drudis.2019.09.006. Epub 2019 Sep 13.

Abstract

A systematic review on how to design different programmable nanotherapeutics using oligonucleotides as building blocks or as surface and matrix modifiers for controlled and targeted delivery of various therapeutic agents in presented.

Publication types

  • Research Support, N.I.H., Extramural
  • Systematic Review

MeSH terms

  • Animals
  • DNA / therapeutic use*
  • Drug Design
  • Humans
  • Nanomedicine
  • Nanostructures / therapeutic use*
  • Oligonucleotides / therapeutic use*

Substances

  • Oligonucleotides
  • DNA