UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

Rob J Noad; Karl Simpson; Anthony R Fooks; Roger Hewson; Sarah C Gilbert; Mark P Stevens; Margaret J Hosie; Joann Prior; Anna M Kinsey; Gary Entrican; Andrew Simpson; Christopher J M Whitty; Miles W Carroll

doi:10.1016/j.vaccine.2019.09.009

UK vaccines network: Mapping priority pathogens of epidemic potential and vaccine pipeline developments

Vaccine. 2019 Oct 8;37(43):6241-6247. doi: 10.1016/j.vaccine.2019.09.009. Epub 2019 Sep 12.

Authors

Affiliations

¹ Pathobiology and Population Science, The Royal Veterinary College, Hawkshead Lane, Hatfield AL9 7TA, UK. Electronic address: rnoad@rvc.ac.uk.
² JKS Bioscience Ltd, 2 Midanbury Court, 44 Midanbury Lane, Southampton SO18 4HF, UK. Electronic address: Karl.simpson@jksbioscience.co.uk.
³ Animal and Plant Health Agency, Weybridge, UK. Electronic address: Tony.Fooks@apha.gsi.gov.uk.
⁴ National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK.
⁵ Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK. Electronic address: sarah.gilbert@ndm.ox.ac.uk.
⁶ The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK. Electronic address: Mark.Stevens@roslin.ed.ac.uk.
⁷ MRC-University of Glasgow Centre for Virus Research, College of Veterinary, Medical and Life Sciences, Garscube Estate, Bearsden, Glasgow G61 1QH, UK. Electronic address: margaret.hosie@glasgow.ac.uk.
⁸ CBR Division, Dstl Porton Down, Wiltshire SP3 4DZ, UK. Electronic address: jlprior@dstl.gsi.gov.uk.
⁹ Medical Research Council, One Kemble Street, London WC2B 4AN, UK. Electronic address: anna.kinsey@mrc.ukri.org.
¹⁰ Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Near Edinburgh, Scotland EH26 0PZ, UK. Electronic address: Gary.Entrican@moredun.ac.uk.
¹¹ National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. Electronic address: Andrew.simpson@phe.gov.uk.
¹² London School of Hygiene & Tropical Medicine, Keppel St., London WC1E 7HT, UK. Electronic address: christopher.whitty@lshtm.ac.uk.
¹³ National Infection Service, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. Electronic address: miles.carroll@phe.gov.uk.

Abstract

During the 2013-2016 Ebola outbreak in West Africa an expert panel was established on the instructions of the UK Prime Minister to identify priority pathogens for outbreak diseases that had the potential to cause future epidemics. A total of 13 priority pathogens were identified, which led to the prioritisation of spending in emerging diseases vaccine research and development from the UK. This meeting report summarises the process used to develop the UK pathogen priority list, compares it to lists generated by other organisations (World Health Organisation, National Institutes of Allergy and Infectious Diseases) and summarises clinical progress towards the development of vaccines against priority diseases. There is clear technical progress towards the development of vaccines. However, the availability of these vaccines will be dependent on sustained funding for clinical trials and the preparation of clinically acceptable manufactured material during inter-epidemic periods.

Keywords: Epidemic; Outbreak; Pathogen; Priority; UKVN; Vaccine.

MeSH terms

Africa, Western / epidemiology
Biomedical Research / organization & administration*
Communicable Disease Control
Communicable Diseases / epidemiology
Communicable Diseases / virology
Communicable Diseases, Emerging / prevention & control*
Communicable Diseases, Emerging / virology
Congresses as Topic
Ebola Vaccines
Epidemics / prevention & control*
Hemorrhagic Fever, Ebola / prevention & control
Humans
National Institutes of Health (U.S.)
United Kingdom
United States
Vaccines*
World Health Organization

Substances

Ebola Vaccines
Vaccines