The cosmetic and pharmaceutical industry is constantly on the lookout for new and efficient active substances. In this article, we focus on resveratrol, an active substance with beneficial health properties, which is obtained, among others, from vines and knotweed (Reynoutria japonica). In this study, we assessed the level of skin hydration in a group of probands who used cream with or without resveratrol. The compound has been shown to have moisturizing and tightening properties, improving the overall condition of the skin.