Model Informed Drug Development: Novel Oncology Agents are Lost in Translation

Clin Cancer Res. 2019 Nov 15;25(22):6564-6566. doi: 10.1158/1078-0432.CCR-19-2482. Epub 2019 Sep 12.

Abstract

Excitement around and investment in oncology drug development are at unprecedented levels. To maximize the health impact and productivity of this research and development investment, quantitative modeling should impact key decisions in early clinical oncology including Go/No-Go decisions based on early clinical data, and dose selection for late stage studies.See related article by Bottino et al., p. 6633.

Publication types

  • Comment

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols*
  • Drug Development
  • Medical Oncology*
  • Therapeutic Index
  • Treatment Outcome