Comparison of two beam angular optimization algorithms guided by automated multicriterial IMRT

Abstract

Purpose: To compare two beam angle optimization (BAO) algorithms for coplanar and non-coplanar geometries in a multicriterial optimization framework.

Methods: 40 nasopharynx patients were selected for this retrospective planning study. IMRT optimized plans were produced by Erasmus-iCycle multicriterial optimization platform. Two different algorithms, based on a discrete and on a continuous exploration of the space search, algorithm i and B respectively, were used to address BAO. Plan quality evaluation and comparison were performed with SPIDERplan. Statistically significant differences between the plans were also assessed.

Results: For plans using only coplanar incidences, the optimized beam distribution with algorithm i is more asymmetric than with algorithm B. For non-coplanar beam optimization, larger deviations from coplanarity were obtained with algorithm i than with algorithm B. Globally, both algorithms presented near equivalent plan quality scores, with algorithm B presenting a marginally better performance than algorithm i.

Conclusion: Almost all plans presented high quality, profiting from multicriterial and beam angular optimization. Although there were not significant differences when average results over the entire sample were considered, a case-by-case analysis revealed important differences for some patients.

Keywords: Beam angular optimization; Multicriteria optimization; Plan quality assessment.