The potential role of regulatory microRNAs of RAS/MAPK signaling pathway in the pathogenesis of colorectal cancer

Atena Soleimani; Farzad Rahmani; Nikoo Saeedi; Rana Ghaffarian; Majid Khazaei; Gordon A Ferns; Amir Avan; Seyed Mahdi Hassanian

doi:10.1002/jcb.29268

The potential role of regulatory microRNAs of RAS/MAPK signaling pathway in the pathogenesis of colorectal cancer

J Cell Biochem. 2019 Dec;120(12):19245-19253. doi: 10.1002/jcb.29268. Epub 2019 Sep 12.

Authors

Atena Soleimani¹, Farzad Rahmani¹, Nikoo Saeedi², Rana Ghaffarian², Majid Khazaei^{3

4}, Gordon A Ferns⁵, Amir Avan^{3

6}, Seyed Mahdi Hassanian^{1

3}

Affiliations

¹ Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
² Student Research Committee, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
³ Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁴ Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Division of Medical Education, Brighton & Sussex Medical School, Brighton, Sussex, UK.
⁶ Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 31512778
DOI: 10.1002/jcb.29268

Abstract

Colorectal cancer (CRC) is the leading cause of cancer death worldwide. Dysregulation of RAS/MAPK signaling axis is frequently found in CRC patients. The RAS/MAPK axis regulates cancer cell proliferation, apoptosis, inflammation, migration, and metastasis. Oncogenic or tumor-suppressor microRNAs (miRNAs) for RAS/MAPK signaling play a key role in the pathogenesis of CRC and are considered as novel potential biomarkers for diagnosis and prognosis of human malignancies. This review summarizes the current knowledge of mechanisms of action of RAS/MAPK miRNAs in the development and progression of CRC for a better understanding and hence a better management of this disease.

Keywords: RAS/MAPK signaling; colorectal cancer; microRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Colorectal Neoplasms / genetics
Colorectal Neoplasms / metabolism*
Gene Expression Regulation, Neoplastic / genetics
Gene Expression Regulation, Neoplastic / physiology
Humans
MAP Kinase Signaling System / genetics
MAP Kinase Signaling System / physiology*
MicroRNAs / genetics
MicroRNAs / metabolism*
Signal Transduction / genetics
Signal Transduction / physiology
ras Proteins / genetics
ras Proteins / metabolism*

Substances

MicroRNAs
ras Proteins