Abstract
The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as α-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol.
Keywords:
boron neutron capture therapy; cancer therapy; carborane; modular system; s-triazine.
MeSH terms
-
Boron / chemistry
-
Boron / pharmacology*
-
Boron Compounds / chemical synthesis
-
Boron Compounds / chemistry
-
Boron Compounds / pharmacology
-
Boron Neutron Capture Therapy*
-
Carboxylic Acids / chemistry
-
Carboxylic Acids / pharmacology
-
Drug Delivery Systems*
-
Esters / chemistry
-
Glycine / chemistry
-
Humans
-
Hydrophobic and Hydrophilic Interactions / drug effects
-
Molecular Structure
-
Neoplasms / drug therapy*
-
Neoplasms / pathology
-
Sulfhydryl Compounds / chemistry
-
Sulfhydryl Compounds / pharmacology
-
Triazines / chemistry
-
Triazines / pharmacology
Substances
-
Boron Compounds
-
Carboxylic Acids
-
Esters
-
Sulfhydryl Compounds
-
Triazines
-
Boron
-
Glycine