Experimental Delineation of Mutational Signatures Is an Essential Tool in Cancer Epidemiology and Prevention

Chem Res Toxicol. 2019 Nov 18;32(11):2153-2155. doi: 10.1021/acs.chemrestox.9b00339. Epub 2019 Sep 11.

Abstract

Advances in experimental modeling of the mutational signatures of environmental exposures and endogenous mutagenic processes will elucidate the role of mutagenesis in cancer, facilitate carcinogen classification, and enable new molecular cancer epidemiology studies.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinogens / toxicity
  • Humans
  • Mutation
  • Neoplasms / epidemiology
  • Neoplasms / genetics*
  • Neoplasms / prevention & control

Substances

  • Carcinogens