A girl, aged 15 months, attended the hospital due to recurrent skin erythema, blisters, and desquamation for more than 7 months. Giemsa staining and immunohistochemical staining showed mast cell infiltration and degranulation. Hematoxylin staining showed spinous layer edema and blister formation under the epidermis, with a large amount of serous fluid and a small number of inflammatory cells in the blister. Marked edema was observed in the dermis, with diffused mononuclear cell infiltration. The girl was diagnosed with mastocytosis. Mastocytosis should be considered for children with recurrent skin erythema and blisters.
患儿，女，15个月，因皮肤反复红斑、水疱和脱屑7月余就诊。吉姆萨染色及免疫组化染色显示肥大细胞浸润并伴有脱颗粒现象；苏木精-伊红染色镜下可见棘层水肿，表皮下水疱形成，疱内可见较多浆液及少量炎症细胞；真皮明显水肿，可见弥散的单一核细胞浸润。患儿确诊为肥大细胞增生症。对于皮肤反复红斑并伴有水疱的患儿，应考虑肥大细胞增生症的可能。