Recent advances in the synthesis of carbazoles from indoles

Org Biomol Chem. 2019 Sep 28;17(36):8330-8342. doi: 10.1039/c9ob01381d. Epub 2019 Sep 9.

Abstract

Carbazoles are privileged nitrogen heterocycles that are present in a wide range of natural products, pharmaceuticals, and functional materials. Due to their wide application, various synthetic strategies are available in the literature using substituted amines or indoles as a substrate. Thus, this review comprehensively highlights the (2015-2019) article that focuses on the synthesis of carbazoles derived from an indole-template through transition-metal catalyzed C-H functionalization, metal-free cyclization, three-component reaction, and electrophilic iodocyclizations. The synthetic strategies described in this review provided diversely substituted carbazoles and few of them have profound pharmacological activity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carbazoles / chemical synthesis*
  • Carbazoles / chemistry
  • Indoles / chemistry*
  • Molecular Structure

Substances

  • Carbazoles
  • Indoles