18F[AlF]-radiolabelled Peptides on the Automated Synthesis Platform: Translating the Laboratory Bench Work to Bedside

Malays J Med Sci. 2019 Jul;26(4):122-126. doi: 10.21315/mjms2019.26.4.14. Epub 2019 Aug 29.

Abstract

Using radiolabelled peptides that bind, with high affinity and specificity, to receptors on tumour cells is one of the most promising fields in modern molecular imaging and targeted radionuclide therapy (1). In the emergence of molecular imaging and nuclear medicine diagnosis and therapy, albeit theranostic, radiolabelled peptides have become vital tools for in vivo visualisation and monitoring physiological and biochemical processes on molecular and cellular levels (2). This approach may benefit patients in the era of personalised medicine.

Keywords: 18F[AlF] method; automated platform; molecular imaging; radiolabelled peptide.