A 24-year-old man (Figure 1) and a 22-year-old woman (Figure 2) with atrophic acne scars were enrolled. Each patient underwent four sessions of treatment with intervals of 4 weeks consecutively, each consisting of microneedling followed by platelet-rich plasma (PRP) application on the right side of the face and microneedling alone on the left. Goodman's qualitative scale was used for the final evaluation of the results. The man had grade 4 acne scars on both sides of the face, which became grade 2 on the right side and grade 3 on the left side (Figure 3). The woman had grade 4 acne scars on both sides of the face, which diminished to grade 1 on the right side and grade 2 on the left side (Figure 4). Improvements were observed after the third treatment.